Oleg Igoshin specializes in computational systems biology with emphasis on dynamical properties and evolutionary design principles of biochemical networks, pattern formation in bacterial biofilms, and genetic networks in bacterial and stem cell development.
Research in Igoshinâ€™s Cellular Systems Dynamics Laboratory uses methods of nonlinear dynamics, biophysics, statistics and bioinformatics to expose emergent properties of biological systems on intercellular and intracellular scales.Â
Igoshinâ€™s computational and theoretical methods complement the experimental approaches of collaborators with leading academic and medical researchers across the U.S., Europe and Australia.
Igoshin joined Rice in 2007. From 2012 to present, he has been instrumental in establishing and growing the doctoral program in Systems, Synthetic, and Physical Biology (SSPB). He has also conducted research as a senior investigator with Riceâ€™s Center for Theoretical Biological Physics since 2013.
Igoshin is an established leader in systems biology modelingâ€™s research with over 50 journal publications in his name. He was awarded an NSF CAREER award (2009) and a John S. Dunn Research Foundation award (2009). His research into thermodynamic models ofÂ combinatorial gene regulation by distant enhancers wasÂ selected for an IET Premium Award in Systems Biology (2011). The award is given by the journalâ€™s editorial board members and editors-in-chief who nominate the â€˜best paper of the yearâ€™ for each journal published by Institute of Engineering and Technology (IET).
Ongoing projects in the Igoshin Research GroupÂ focus on the:
Modeling of microbiological self-organization
Myxococcus xanthus is one of the most intriguing microbes known for its multicellular lifestyle. Under appropriate conditions, bacterial cells collectively move to self-organize to form complex multicellular structures. The Igoshin Group and their collaborators seek to quantitatively characterize and mechanistically understand self-organization and pattern formation M. xanthus and other bacteria. Complementary to traditional experimental research, the Igoshin Group uses computational biophysics and engineering approaches to build mathematical models of these phenomena.
Noise and feedback regulation in bacterial genetic networks
Transcriptional feedbacks are abundant in bacterial gene regulation, but their physiological role is not always well understood. The Igoshin Group investigates the role transcriptional feedback plays in shaping signal response and the characteristics of master-level regulators of bacterial gene expression. The Igoshin Group focuses on major classes of bacterial signaling systems â€“ two-component signal transduction cascades and networks regulating activity of the alternative sigma factors. In particular, the research aims to uncover the stochastic nature of these processes, which allows isogenic bacteria to achieve different responses in identical environmental conditions.
Feedback architectures of transcriptional regulation in hematopoietic stem cells
Transcriptional regulation of multipotent mammalian stem-cell lines is significantly more complex than bacterial regulation and therefore contains more complicated functional network motifs. The Igoshin Group uses mathematical modeling to study how the architecture of these motifs affects their physiological function.
Diffusive-kinetic theories of enzymatic reaction networks
Recent single-molecule experiments have demonstrated that catalytic enzymes often display slow conformational fluctuations that affect their kinetic properties. As a result, macroscopic rate laws describing the enzymatic reaction may deviate from classical biochemical kinetics. The Igoshin Group investigates how fluctuation may affect the kinetics of coupled biochemical reaction networks. Furthermore, Igoshin Group works on quantifying trade-offs between speed, accuracy and precision in enzymatically controlled reactions.Â