Computational and Theoretical Bioengineering
The computational and theoretical bioengineering group works to explain, model, and provide the means to manipulate medically-related biological systems. Investigations range from biomechanics to protein-protein interactions, to stem cell differentiation and immune system therapies. General areas of interest include bone and cartilage mechanics, stress effects on stem cell differentiation, sequence and structure properties of glycosaminoglycans, nanoelectromechanical transduction in cochlear, outer-hair cell membranes, characterization of molecular imaging markers, structural biology, evolution and immune system therapies, design principles of biochemical circuits, and drug-based inhibition of aberrant protein interactions.
Researchers in the Department of Bioengineering involved in this field include:
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Michael W. Deem, Ph.D. .jpg "Click for larger view")
- Newton's laws of biology
- Physical theories of evolution
- Physical theories of evolution
- Structure, nucleation, and function of zeolites
Deem Group
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 Michael Diehl, Ph.D.
- Regulation of intracellular transport
- In situ molecular pathway analyses
Macromolecular Systems Bioengineering Group
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K. Jane Grande-Allen, Ph.D. 
- Constitutive modeling of the material behavior of native
and tissue engineered heart valves
- Diversity of glycsaminoglycan structures
- Patient-specific modeling of heart valve disease and surgical repair
Grande-Allen Integrative Matrix Mechanics Lab
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 Oleg A. Igoshin, Ph.D.
- Modeling self-organization and pattern formation in cellular systems
- Deterministic and stochastic models of biochemical networks
- Systems biology modeling of differentiation and development
Cellular System Dynamics Group
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 Jeffrey Jacot, Ph.D.
- Computational finite element modeling of congenital heart defects
- Voltage mapping of the whole heart
Jacot Laboratory
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Jianpeng Ma, Ph.D. 
- Computational simulation of biomolecular dynamics
- Structural refinement against low-resolution experimental data
- Structure prediction and folding
- Structure-based drug design
- Bioinformatics
Ma Laboratory
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Amina A. Qutub, Ph.D. 
- Regulation of intracellular hypoxic response in ischemia and cancer
- Neurogenesis and angiogenesis signaling
- Algorithm development for cell-level modeling coupled to imaging
Microvascular Systems Biology Laboratory
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Robert Raphael, Ph.D.
- Auditory Systems Biology
- Micromechanical Biosystems
Membrane and Auditory Bioengineering Group
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Ka-Yiu San, Ph.D. 
- Metabolic and genetic engineering
- Systems biotechnology
- Genetic architecture and phenotype
Metabolic Engineering and Systems Biotechnology Laboratory
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